Journal: ACS Omega
Article Title: Inhibition of Growth and Biofilm Formation in Staphylococcus aureus by LLY-507
doi: 10.1021/acsomega.5c10668
Figure Lengend Snippet: Planktonic cells of MSSA SA113 (A) and MRSA YUSA145 (B) were treated with 1/16×, 1/8×, 1/4×, 1/2×, 1× MIC of LLY-507. The LLY-507 MIC for these S. aureus clinical isolates was 25 μM. The OD 600 of the bacterial cells was then measured by Bioscreen C (Turku, Finland) at 1-h intervals for 24 h. TSB without antimicrobials was used as the untreated control. Data are shown as mean ± SD, n = 3. Time-killing curve of LLY-507 against clinical MRSA (YUSA145) and the impact of LLY-507 on the growth curves of S. aureus planktonic cells. Bacterial cultures in the logarithmic growth phase (OD 600 = 0.6–0.8) were treated with 2× MIC of LLY-507, Vancomycin (Van), and Linezolid (LZD) separately (C). Bacterial cultures in the stationary phase (OD 600 > 3) were treated with 2× MIC of LLY-507, Vancomycin, and Linezolid, followed by overnight incubation (D). Bactericidal curves were plotted accordingly.
Article Snippet: Antibiotics LLY-507, Vancomycin (Van), and Linezolid (LZD) were bought from MCE.
Techniques: Control, Incubation